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Keion White says he hopes the 3-13 New England Patriots are on track to make major changes this offseason. "If changes aren't made, then what are we doing?" White asked after the Patriots recorded a sixth straight loss on Saturday against the Los Angeles Chargers (h/t Mike Giardi of Boston Sports Journal. ) When asked what changes he was hoping for, White answered, "That's not for me to decide." Patriots wideout Pop Douglas sounded similarly dispirited after Saturday's loss. "I'm just tired of losing," Douglas said, per Giardi . The Patriots last won a game on Nov. 10 in Week 10 action against the Chicago Bears. The team has been eliminated from playoff contention since Week 13. This article will be updated soon to provide more information and analysis. For more from Bleacher Report on this topic and from around the sports world, check out our B/R app , homepage and social feeds—including Twitter , Instagram , Facebook and TikTok .Agomelatine is a small molecule commercialized by Alto Neuroscience, with a leading Phase II program in Major Depressive Disorder. According to Globaldata, it is involved in 3 clinical trials, of which 2 were completed, and 1 is ongoing. Smarter leaders trust GlobalData The gold standard of business intelligence. The revenue for Agomelatine is expected to reach an annual total of $104 mn by 2039 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress. Agomelatine Overview Agomelatine (ALTO-300) is under development for the treatment of major depressive disorder (MDD). It is administered through oral route. It acts by targeting MT1, MT2 and 5-HT2C. It was also under development for post-traumatic stress disorder (PTSD). Alto Neuroscience Overview Alto Neuroscience is a biopharmaceutical company that develops drugs for psychiatric and mental health conditions. It is investigating ALTO-100, ALTO-202, and ALTO-300 drugs for the treatment of major depressive disorder (MDD) and post-traumatic stress disorder (PTSD) by targeting cognition, emotion, and sleep systems. The company utilizes its AI-enabled drug development platform that identifies biomarkers by evaluating brain function measures to develop its product candidates. It serves throughout the US. Alto Neuroscience is headquartered in Los Altos, California, the US. The operating loss of the company was US$37.8 million in FY2023, compared to an operating loss of US$29.2 million in FY2022. The net loss of the company was US$36.3 million in FY2023, compared to a net loss of US$27.7 million in FY2022. For a complete picture of Agomelatine’s valuation, From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company. The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s .abc jili 。

Chewy, Inc. ( NYSE:CHWY – Get Free Report ) CEO Sumit Singh sold 71,161 shares of the firm’s stock in a transaction on Tuesday, December 24th. The stock was sold at an average price of $35.00, for a total value of $2,490,635.00. Following the transaction, the chief executive officer now owns 6,677 shares in the company, valued at $233,695. The trade was a 91.42 % decrease in their ownership of the stock. The transaction was disclosed in a document filed with the Securities & Exchange Commission, which is available through this link . Sumit Singh also recently made the following trade(s): Chewy Price Performance Chewy stock opened at $34.07 on Friday. The stock has a market capitalization of $13.87 billion, a price-to-earnings ratio of 37.44, a PEG ratio of 4.28 and a beta of 1.12. Chewy, Inc. has a 1-year low of $14.69 and a 1-year high of $39.10. The business has a fifty day moving average price of $31.66 and a 200-day moving average price of $28.54. Institutional Trading of Chewy A number of institutional investors and hedge funds have recently added to or reduced their stakes in CHWY. BC Partners Advisors L.P. acquired a new stake in Chewy during the 2nd quarter worth about $7,517,800,000. Marshall Wace LLP lifted its position in Chewy by 1,028.6% during the 2nd quarter. Marshall Wace LLP now owns 2,892,841 shares of the company’s stock worth $78,801,000 after acquiring an additional 2,636,526 shares during the period. FMR LLC lifted its position in Chewy by 166.8% during the 3rd quarter. FMR LLC now owns 3,995,329 shares of the company’s stock worth $117,023,000 after acquiring an additional 2,497,689 shares during the period. Fiera Capital Corp acquired a new stake in Chewy during the 2nd quarter worth about $44,373,000. Finally, Clearbridge Investments LLC acquired a new stake in Chewy during the 2nd quarter worth about $40,798,000. Institutional investors and hedge funds own 93.09% of the company’s stock. Analyst Ratings Changes CHWY has been the topic of several research reports. JPMorgan Chase & Co. raised their price objective on Chewy from $37.00 to $38.00 and gave the stock an “overweight” rating in a report on Thursday, December 5th. Wedbush reaffirmed an “outperform” rating and set a $39.00 target price (up previously from $35.00) on shares of Chewy in a research report on Thursday, December 5th. JMP Securities reaffirmed a “market outperform” rating and set a $37.00 target price on shares of Chewy in a research report on Monday, December 16th. Bank of America raised Chewy from an “underperform” rating to a “buy” rating and increased their target price for the company from $24.00 to $40.00 in a research report on Wednesday, November 20th. Finally, Citigroup raised Chewy from a “neutral” rating to a “buy” rating and increased their target price for the company from $28.00 to $40.00 in a research report on Friday, November 8th. Nine investment analysts have rated the stock with a hold rating and fourteen have issued a buy rating to the company’s stock. Based on data from MarketBeat, Chewy currently has a consensus rating of “Moderate Buy” and a consensus price target of $34.60. Read Our Latest Stock Report on CHWY About Chewy ( Get Free Report ) Chewy, Inc, together with its subsidiaries, engages in the pure play e-commerce business in the United States. It provides pet food and treats, pet supplies and pet medications, and other pet-health products, as well as pet services for dogs, cats, fish, birds, small pets, horses, and reptiles through its retail websites and mobile applications. Recommended Stories Receive News & Ratings for Chewy Daily - Enter your email address below to receive a concise daily summary of the latest news and analysts' ratings for Chewy and related companies with MarketBeat.com's FREE daily email newsletter .

Science and Technology Daily: Promoting AI Governance Jointly

NoneA range of independent TDs are contemplating the prospect of entering Ireland’s next coalition government as Fianna Fáil and Fine Gael consider ways to secure a solid majority. With only two of the Dáil 's174 seats left to be decided, Fianna Fáil is the clear winner of Friday’s general election and is set to emerge with the most TDs on 48. Advertisement Sinn Féin will take 39 and Fine Gael 38. The return of a Fianna Fáil/Fine Gael-led coalition is now highly likely. However, their predicted combined seat total of 86 would leave them just short of the 88 needed for a majority in the Dáil. Advertisement Fianna Fail leader Micheal Martin is hoisted up by his sons Cillian and Micheal Aodh after he was deemed elected in the Cork South Central constituency on Saturday (Jacob King/PA) While the two centrist parties that have dominated Irish politics for a century could look to strike a deal with one of the Dáil’s smaller centre-left parties, such as the Social Democrats or Labour, a more straightforward route to a majority could be achieved by securing the support of several independent TDs. For Fianna Fail leader Micheal Martin and current taoiseach and Fine Gael leader Simon Harris, wooing like-minded independents would be likely to involve fewer policy concessions, and financial commitments, than would be required to convince another party to join the government benches. Longford-Westmeath independent TD Kevin “Boxer” Moran, who served in a Fine Gael-led minority government between 2017 and 2020, expressed his willingness to listen to offers to join the new coalition in Dublin. Advertisement “Look, my door’s open,” he told RTÉ. “Someone knocks, I’m always there to open it.” Marian Harkin, an independent TD for Sligo-Leitrim, expressed her desire to participate in government as she noted that Fianna Fáil and Fine Gael were within “shouting distance” of an overall majority. “That means they will be looking for support, and I certainly will be one of those people who will be speaking to them and talking to them and negotiating with them, and I’m looking forward to doing that, because that was the reason that I ran in the first place,” she said. Meanwhile, the Social Democrats and Labour Party both appear cautious about the prospect of an alliance both parties. Advertisement They will no doubt be mindful of the experience of the Green Party, the junior partner in the last mandate. The Greens experienced near wipeout in the election, retaining only one of their 12 seats. Taoiseach Simon Harris is hugged by his wife Caoimhe after being re-elected to the Dail parliament as a TD for Wicklow (Niall Carson/PA) Sinn Féin appears to currently have no realistic route to government, given Fianna Fail and Fine Gael’s ongoing refusal to share power with the party. Advertisement Despite the odds being stacked against her party, Sinn Féin president Mary Lou McDonald contacted the leaders of the Social Democrats and Labour on Monday to discuss options. Earlier, Fianna Fáil deputy leader and outgoing Finance Minister Jack Chambers predicted that a new coalition government would not be in place before Christmas. Mr Chambers said planned talks about forming an administration required “time and space” to ensure that any new government will be “coherent and stable”. After an inconclusive outcome to the 2020 election, it took five months for Fianna Fáil, Fine Gael and the Greens to strike the last coalition deal. Mr Chambers said he did not believe it would take that long this time, as he noted the Covid-19 pandemic was a factor in 2020, but he also made clear it would not be a swift process. He said he agreed with analysis that there was no prospect of a deal before Christmas. “I don’t expect a government to be formed in mid-December, when the Dáil is due to meet on December 18th, probably a Ceann Comhairle (speaker) can be elected, and there’ll have to be time and space taken to make sure we can form a coherent, stable government,” he told RTÉ. “I don’t think it should take five months like it did the last time – Covid obviously complicated that. But I think all political parties need to take the time to see what’s possible and try and form a stable government for the Irish people.” Independent TD Kevin ‘Boxer’ Moran took a hands-on approach to dealing with flooding in Co Westmeath while a minister of state in 2020 (Brian Lawless/PA) Fine Gael minister of state Peter Burke said members of his parliamentary party would have to meet to consider their options before giving Mr Harris a mandate to negotiate a new programme for government with Fianna Fail. “It’s important that we have a strong, stable, viable government, whatever form that may be, to ensure that we can meet the challenges of our society, meet the challenges in terms of the economic changes that are potentially going to happen,” he told RTE. Despite being set to emerge with the most seats, it has not been all good news for Fianna Fail. The party’s outgoing Health Minister Stephen Donnelly became one of the biggest casualties of the election when he lost his seat in Wicklow in the early hours of Monday morning. Mr Donnelly was always predicted to face a fight in the constituency after boundary changes saw it reduced from five to four seats.

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It's been feast or famine for Marvin Harrison Jr . all season long. He's averaging 11.5 Fantasy points per game, but the consistency every week has left much to be desired. In 13 weeks, Harrison has scored double-digit Fantasy points just six times. If it wasn't for a Week 2 29-point explosion against the Los Angeles Chargers and his Week 8 23-point outing against the Miami Dolphins , his 11.5 Fantasy points per game would be even lower. Harrison is ranked 30th among all Fantasy wide receivers, and he's starting in 69% of all leagues. While Harrison is only a rookie, there's plenty of reason to be satisfied with his performance so far. Heath Cummings was asked on the Week 13 Fantasy Recap podcast if Harrison was his top rookie wide receiver. While he spoke glowingly of Harrison, he had another WR in mind as his No. 1 rookie. "It's probably still Malik Nabers , but Marvin Harrison Jr. would probably be second for me," Heath said. "Next week's matchup is probably the worst that he has all season long, and it's the week where six teams are on a bye. But then you get the Patriots , you get the Panthers , and I'm not too scared of the Rams . If they finally, for some reason, start throwing him the ball double-digit times per game, he might, in the Fantasy playoffs, justify his ADP. Now, I'm not sure how many people drafted him in Round 2 that are going to make the Fantasy playoffs, but he might be that guy as a borderline No. 1 wide receiver in the last three weeks of the Fantasy season." Nabers commands a much higher target share than Harrison and has averaged 16.2 Fantasy points so far this year. He's clearly the top rookie wide receiver, and when the Giants can improve at the quarterback position, he's going to be that much more productive. Harrison, on the other hand, is already playing alongside a top-tier quarterback. Unfortunately, there doesn't seem to be any emphasis on getting him the football. In fact, Kyler Murray said earlier in the year in reference to Harrison's lack of production: "As a quarterback going through your reads, sometimes the ball goes to him. It's (targeting Harrison) not my job." When you take a wide receiver with the No. 4 overall pick, getting him the ball frequently should be a part of the game plan, but apparently, that isn't the case in Arizona. The reason Harrison hasn't made the big splash everyone believes he should've made as a rookie is that the Cardinals have had their fair share of protection issues. They've elected to use more 12 personnel (one back and two running backs) to help keep Kyler Murray upright. Unfortunately, due to protection issues, the deeper routes Harrison is running rarely have time to develop unless Murray is able to extend the play with his legs. This means the tight ends are going to be targeted on shallow crossing routes much more consistently. As it stands, Harrison is "decoy boy," especially when the run game isn't having much success. When the run game is working, there's always a chance that a deep shot off play-action may happen. Harrison will surely be targeted more in the future, but the way this team is presently constructed stifles his productivity. Given the condensed splits and personnel groupings, this Cardinals offense is very similar to Greg Roman's offense in Baltimore. One thing I do like is that in the red zone, the Cardinals offense is spreading defenses out. While there are still two tight ends in the game, they're lined up at wide receiver, and this will often leave Harrison manned up while Murray uses his legs to buy time. The Cardinals will face the Seattle Seahawks in Week 14, and their pass defense is currently ranked No. 15 in the NFL . He's expected to reach 13.7 Fantasy points, but he could have a tough time separating against Riq Woolen. I would expect him to underperform a bit in Seattle, but after that, the Cardinals face the Patriots, Panthers, Rams, and a depleted 49ers team. As Heath said, given the matchups, he could be a factor in the playoffs. For more Fantasy insight, be sure to check out the entire Week 13 Fantasy Recap – or watch (and subscribe) on Youtube .Trump going berserk, targets birthright, naturalized citizensPrincipal Financial Group Inc. lifted its holdings in Nu Holdings Ltd. ( NYSE:NU – Free Report ) by 315.8% in the 3rd quarter, according to the company in its most recent disclosure with the SEC. The institutional investor owned 1,153,464 shares of the company’s stock after purchasing an additional 876,039 shares during the quarter. Principal Financial Group Inc.’s holdings in NU were worth $15,745,000 as of its most recent filing with the SEC. A number of other large investors also recently modified their holdings of the business. Bank of New York Mellon Corp increased its stake in shares of NU by 33.9% during the second quarter. Bank of New York Mellon Corp now owns 5,832,111 shares of the company’s stock valued at $75,176,000 after acquiring an additional 1,476,325 shares during the period. Allspring Global Investments Holdings LLC grew its holdings in NU by 64.4% during the second quarter. Allspring Global Investments Holdings LLC now owns 14,536 shares of the company’s stock worth $187,000 after acquiring an additional 5,695 shares during the period. Cambridge Investment Research Advisors Inc. raised its position in NU by 9.7% in the second quarter. Cambridge Investment Research Advisors Inc. now owns 351,523 shares of the company’s stock worth $4,531,000 after acquiring an additional 31,096 shares in the last quarter. HB Wealth Management LLC acquired a new stake in NU during the second quarter valued at approximately $140,000. Finally, Crossmark Global Holdings Inc. boosted its holdings in NU by 1.4% during the second quarter. Crossmark Global Holdings Inc. now owns 161,018 shares of the company’s stock worth $2,076,000 after buying an additional 2,255 shares in the last quarter. 84.02% of the stock is owned by institutional investors and hedge funds. Analysts Set New Price Targets A number of equities analysts recently issued reports on NU shares. Bank of America lifted their target price on NU from $12.80 to $15.00 and gave the stock a “neutral” rating in a report on Thursday, September 12th. Citigroup lowered shares of NU from a “neutral” rating to a “sell” rating and cut their price target for the company from $14.60 to $11.00 in a report on Monday, December 2nd. KeyCorp lifted their price objective on shares of NU from $15.00 to $17.00 and gave the stock an “overweight” rating in a research report on Thursday, November 14th. Itau BBA Securities downgraded shares of NU from an “outperform” rating to a “market perform” rating in a research report on Thursday, November 14th. Finally, Susquehanna upped their price target on shares of NU from $16.00 to $18.00 and gave the stock a “positive” rating in a research note on Thursday, November 14th. One equities research analyst has rated the stock with a sell rating, four have issued a hold rating and five have given a buy rating to the company’s stock. According to MarketBeat, the stock presently has an average rating of “Hold” and a consensus target price of $15.63. NU Stock Down 0.3 % Shares of NU stock opened at $10.33 on Friday. The company has a quick ratio of 0.44, a current ratio of 0.44 and a debt-to-equity ratio of 0.20. The stock has a 50 day moving average price of $13.25 and a two-hundred day moving average price of $13.28. The stock has a market capitalization of $49.23 billion, a P/E ratio of 28.69, a PEG ratio of 0.59 and a beta of 0.99. Nu Holdings Ltd. has a 12-month low of $8.06 and a 12-month high of $16.15. About NU ( Free Report ) Nu Holdings Ltd. provides digital banking platform and digital financial services in Brazil, Mexico, Colombia, and internationally. It offers Nu credit and debit cards; Ultraviolet credit and debit cards; and mobile payment solutions for NuAccount customers to make and receive transfers, pay bills, and make everyday purchases through their mobile phones. Further Reading Want to see what other hedge funds are holding NU? Visit HoldingsChannel.com to get the latest 13F filings and insider trades for Nu Holdings Ltd. ( NYSE:NU – Free Report ). Receive News & Ratings for NU Daily - Enter your email address below to receive a concise daily summary of the latest news and analysts' ratings for NU and related companies with MarketBeat.com's FREE daily email newsletter .